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NDE1 Antibody (PA5-119857) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded rat cerebellum tissue using NDE1 Polyclonal Antibody (Product # PA5-119857). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the NDE1 antibody at a dilution of ... View More
产品信息
PA5-119857
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein within human NDE1 aa 1-200
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2913429
产品详细信息
Positive Control: Rat brain tissue lysates, rat cerebellum tissue, human liver tissue.
Subcellular Location: Cytoskeleton, centrosome, spindle, kinetochore, cleavage furrow.
靶标信息
NDE1 is s a member of the nuclear distribution E (NudE) family of proteins. It is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. NDE1 protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations to the gene lead to Lissencephaly 4 (LIS4) and Microhydranencephaly (MHAC).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: LIS1-interacting protein NUDE1; LIS1-interacting protein NUDE1, rat homolog; nuclear distribution gene E homolog 1; Nuclear distribution protein nudE homolog 1; NudE; nudE nuclear distribution E homolog 1; nudE nuclear distribution gene E homolog 1; rNudE
基因别名: HOM-TES-87; LIS4; MHAC; NDE; NDE1; NUDE; NUDE1
UniProt ID: (Human) Q9NXR1, (Rat) Q9ES39
Entrez Gene ID: (Human) 54820, (Rat) 83836
establishment of mitotic spindle orientation
neuron migration
microtubule nucleation
chromosome segregation
mitotic centrosome separation
neuroblast proliferation
cell migration
cerebral cortex development
forebrain development
microtubule organizing center organization
vesicle transport along microtubule
centrosome duplication
cell division
establishment of chromosome localization
centrosome localization
G2/M transition of mitotic cell cycle
sister chromatid cohesion
regulation of microtubule motor activity
