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NDRG1 Antibody (PA5-148239) in ICC/IF
Immunocytochemistry analysis of NDRG1 in Hela cells. Samples were incubated with NDRG1 polyclonal antibody (Product # PA5-148239) using a dilution of 1:1,000 at 4°C overnight followed by Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green. Cells were fixed with 4% PFA, permeabilized with 0.3% Triton X-100 in PBS, and blocked with 10% serum). Positive staining was localized to cytoplasm and nucleus.
产品信息
PA5-148239
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human NDRG1/CAP43 Protein (Met1-Cys394)
偶联物
形式
Liquid
浓度
100 µg/mL
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
NDRG1 is a 394 amino acid cytoplasmic protein belonging to the NDRG family. It interacts with APO A-I and A-II and plays a role in HDL-mediated cholesterol transport, stress responses, hormone responses, cell growth and differentiation. Its defect causes Charcot-Marie-Tooth disease type 4D (CMT4D) that is characterized by reduced nerve conduction velocities, segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes and hollow feet. NDRG1 plays a growth inhibitory role and serves as a marker of differentiation. It is expressed in placental membranes, prostate, kidney, small intestine, ovary tissues, colon and the cells that border the lumen.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Differentiation-related gene 1 protein; DRG-1; N-myc downstream-regulated gene 1 protein; Nickel-specific induction protein Cap43; Protein NDRG1; protein regulated by oxygen-1; Reducing agents and tunicamycin-responsive protein; Rit42; RTP
基因别名: CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL; NDR1; NDRG1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5
UniProt ID: (Human) Q92597
Entrez Gene ID: (Human) 10397
negative regulation of cell proliferation
response to metal ion
DNA damage response, signal transduction by p53 class mediator
peripheral nervous system myelin maintenance
regulation of apoptotic process
mast cell activation
cellular response to hypoxia
positive regulation of spindle checkpoint
cell-cell adhesion
