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NDRG1 Antibody (PA5-27213) in IHC (P)
NDRG1 Polyclonal Antibody detects NDRG1 protein at membrane on human liver carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded liver carcinoma. NDRG1 Polyclonal Antibody (Product # PA5-27213) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-27213
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 186 and 369 of Human NDRG1
偶联物
形式
Liquid
浓度
0.67 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2544689
产品详细信息
Recommended positive controls: 293T, HepG2, NIH-3T3.
Predicted reactivity: Mouse (98%), Rat (98%), Xenopus laevis (85%), Dog (98%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
NDRG1 is a 394 amino acid cytoplasmic protein belonging to the NDRG family. It interacts with APO A-I and A-II and plays a role in HDL-mediated cholesterol transport, stress responses, hormone responses, cell growth and differentiation. Its defect causes Charcot-Marie-Tooth disease type 4D (CMT4D) that is characterized by reduced nerve conduction velocities, segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes and hollow feet. NDRG1 plays a growth inhibitory role and serves as a marker of differentiation. It is expressed in placental membranes, prostate, kidney, small intestine, ovary tissues, colon and the cells that border the lumen.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Differentiation-related gene 1 protein; DRG-1; N-myc downstream regulated 1; N-myc downstream-regulated gene 1 protein; Nickel-specific induction protein Cap43; Protein Ndr1; Protein NDRG1; protein regulated by oxygen-1; Reducing agents and tunicamycin-responsive protein; Rit42; RTP
基因别名: CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL; NDR1; NDRG1; Ndrl; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5
UniProt ID: (Human) Q92597, (Mouse) Q62433
Entrez Gene ID: (Human) 10397, (Mouse) 17988
negative regulation of cell proliferation
response to metal ion
DNA damage response, signal transduction by p53 class mediator
peripheral nervous system myelin maintenance
regulation of apoptotic process
mast cell activation
cellular response to hypoxia
positive regulation of spindle checkpoint
cell-cell adhesion
signal transduction
