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NDUFA13 Antibody (43-8900) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of GRIM19 in cultured human fibroblasts using a NDUFA13 Monoclonal Antibody (Product # 43-8900) at a concentration of 1 µg/mL. Cultured Human fibroblasts were fixed, permeabilized and then detected by Alexa® 488 goat-anti-mouse IgG.
产品信息
43-8900
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human,
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
6E1BH7
抗原
Full-length recombinant human GRIM-19
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
HEPES buffered saline
内含物
0.02% sodium azide
保存条件
4° C, do not freeze
运输条件
Wet ice
RRID
AB_2533544
产品详细信息
Positive control: Human heart, Bovine heart, Rat heart, and Mouse heart isolated mitochondria, Human fibroblasts, HeLa cells
靶标信息
A novel gene associated with Retinoid-IFN-induced Mortality (GRIM) GRIM-19 gene was identified. Antisense expression of GRIM-19 confers a strong resistance against IFN/RA-induced death by reducing the intracellular levels of GRIM-19 protein. Overexpression of GRIM-19 enhances cell death in response to IFN/RA. GRIM-19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM-19 is a novel cell death-regulatory molecule.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cell d; Cell death regulatory protein GRIM-19; cell death-regulatory protein GRIM19; CI-B16.6; complex I B16.6 subunit; Complex I-B16.6; FLJ58045; FLJ59191; gene associated with retinoic and IFN-induced mortality 19 protein; Gene associated with retinoic and interferon-induced mortality 19 protein; Gene associated with retinoic-interferon-induced mortality 19 protein; genes associated with retinoid-IFN-induced mortality 19; GRIM-19; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; NADH-ubiquinone oxidoreductase B16.6 subunit
基因别名: 2700054G14Rik; AU022060; B16.6; CDA016; CGI-39; GRIM-19; GRIM19; NDUFA13
UniProt ID: (Human) Q9P0J0, (Bovine) Q95KV7, (Mouse) Q9ERS2
Entrez Gene ID: (Rat) 100911483, (Human) 51079, (Bovine) 338084, (Mouse) 67184
mitochondrial electron transport, NADH to ubiquinone
positive regulation of peptidase activity
negative regulation of cell growth
mitochondrial respiratory chain complex I assembly
cellular response to interferon-beta
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein import into mitochondrial inner membrane
positive regulation of protein catabolic process
negative regulation of transcription, DNA-templated
cellular response to retinoic acid
reactive oxygen species metabolic process
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway
oxidation-reduction process
