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产品信息
PA5-42179
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human NELF (aa 2-51).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2607182
产品详细信息
Peptide sequence: GAAASRRRAL RSEAMSSVAA KVRAARAFGE YLSQSHPENR NGADHLLADA
Sequence homology: Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 79%; Rat: 100%
靶标信息
NELF (nasal embryonic luteinizing hormone-releasing hormone factor) is a 530 amino acid transcription factor involved in the migration of LHRH neurons, outgrowth of olfactory axons and suppression of transcription elongation. NELF is found in the peripheral and central nervous system during embryonic development, and is highly expressed in adult testis, kidney and brain. Known to couple NMDA receptor signaling to the nucleus, NELF knockdown impaired GnRH neuronal migration of NLT cells in vitro and the gene encoding NELF has been linked to the development of Idiopathic hypogonadotropic hypogonadism (IHH), a disorder resulting in impaired pubertal maturation and reproductive function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Nasal embryonic LHRH factor; Nasal embryonic luteinizing hormone-releasing hormone factor; NMDA receptor synaptonuclear signaling and neuronal migration factor
基因别名: HH9; NELF; NSMF
UniProt ID: (Human) Q6X4W1
Entrez Gene ID: (Human) 26012
positive regulation of protein dephosphorylation
regulation of neuron apoptotic process
regulation of neuronal synaptic plasticity
regulation of dendrite morphogenesis
cellular response to amino acid stimulus
cellular response to electrical stimulus
cellular response to gonadotropin stimulus
positive regulation of neuron migration
