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产品信息
PA5-60674
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2644816
产品详细信息
Immunogen sequence: KLNVYHKGAK IWKMLIFCQG GPGHLYLLKN KVATFAKVEK EEDMIHFWKR LSRLMSKVNP EPNVIHIMGC YILGNPNGEK LFQNLRTLMT PYRVTFESPL ELSAQGKQMI ETYFDFRL
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
靶标信息
NELF (nasal embryonic luteinizing hormone-releasing hormone factor) is a 530 amino acid transcription factor involved in the migration of LHRH neurons, outgrowth of olfactory axons and suppression of transcription elongation. NELF is found in the peripheral and central nervous system during embryonic development, and is highly expressed in adult testis, kidney and brain. Known to couple NMDA receptor signaling to the nucleus, NELF knockdown impaired GnRH neuronal migration of NLT cells in vitro and the gene encoding NELF has been linked to the development of Idiopathic hypogonadotropic hypogonadism (IHH), a disorder resulting in impaired pubertal maturation and reproductive function.
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生物信息学
蛋白别名: Nasal embryonic LHRH factor; Nasal embryonic luteinizing hormone-releasing hormone factor; NMDA receptor synaptonuclear signaling and neuronal migration factor
基因别名: HH9; NELF; NSMF
UniProt ID: (Human) Q6X4W1
Entrez Gene ID: (Human) 26012
positive regulation of protein dephosphorylation
regulation of neuron apoptotic process
regulation of neuronal synaptic plasticity
regulation of dendrite morphogenesis
cellular response to amino acid stimulus
cellular response to electrical stimulus
cellular response to gonadotropin stimulus
positive regulation of neuron migration
