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NELF Antibody (PA5-92264) in WB
Western blot analysis of NELF in extracts of various cell lines. Samples were incubated with NELF Polyclonal antibody (Product # PA5-92264) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-92264
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 226-505 of human NSMF (NP_0011244431)
偶联物
形式
Liquid
浓度
3.3 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806425
产品详细信息
Immunogen sequence: FQTATTTMQA NFRKHLRMVG SRRVKAQTFA ERRERSFSRS WSDPTPMKAD TSHDSRDSSD LQSSHCTLDE AFEDLDWDTE KGLEAVACDT EGFVPPKVML ISSKVPKAEY IPTIIRRDDP SIIPILYDHE HATFEDILEE IERKLNVYHK GAKIWKMLIF CQGGPGHLYL LKNKVATFAK VEKEEDMIHF WKRLSRLMSK VNPEPNVIHI MGCYILGNPN GEKLFQNLRT LMTPYRVTFE SPLELSAQGK QMIETYFDFR LYRLWKSRQH SKLLDFDDVL; Positive Samples: LO2, HT-29, 293T, BT-474, Mouse brain; Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus, Nucleus envelope, Nucleus matrix, Nucleus membrane, Peripheral membrane protein, cell cortex, cytoskeleton, dendrite, postsynaptic cell membrane, postsynaptic density, synapse, synaptosome
靶标信息
NELF (nasal embryonic luteinizing hormone-releasing hormone factor) is a 530 amino acid transcription factor involved in the migration of LHRH neurons, outgrowth of olfactory axons and suppression of transcription elongation. NELF is found in the peripheral and central nervous system during embryonic development, and is highly expressed in adult testis, kidney and brain. Known to couple NMDA receptor signaling to the nucleus, NELF knockdown impaired GnRH neuronal migration of NLT cells in vitro and the gene encoding NELF has been linked to the development of Idiopathic hypogonadotropic hypogonadism (IHH), a disorder resulting in impaired pubertal maturation and reproductive function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Jacob protein; Juxtasynaptic attractor of caldendrin on dendritic boutons protein; Nasal embryonic LHRH factor; Nasal embryonic luteinizing hormone-releasing hormone factor; NMDA receptor synaptonuclear signaling and neuronal migration factor
基因别名: HH9; Jac; Jacob; NELF; NSMF
UniProt ID: (Human) Q6X4W1, (Mouse) Q99NF2
Entrez Gene ID: (Human) 26012, (Mouse) 56876
positive regulation of protein dephosphorylation
regulation of neuron apoptotic process
regulation of neuronal synaptic plasticity
regulation of dendrite morphogenesis
cellular response to amino acid stimulus
cellular response to electrical stimulus
cellular response to gonadotropin stimulus
positive regulation of neuron migration
