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NEU1 Antibody (PA5-92879) in IHC (P)
Immunohistochemistry analysis of NEU1 in paraffin-embedded mouse kidney. Samples were incubated with NEU1 Polyclonal antibody (Product # PA5-92879) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
PA5-92879
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 210-415 of human NEU1 (NP_0004251)
偶联物
形式
Liquid
浓度
0.95 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806528
产品详细信息
Immunogen sequence: PRKGRLIVCG HGTLERDGVF CLLSDDHGAS WRYGSGVSGI PYGQPKQEND FNPDECQPYE LPDGSVVINA RNQNNYHCHC RIVLRSYDAC DTLRPRDVTF DPELVDPVVA AGAVVTSSGI VFFSNPAHPE FRVNLTLRWS FSNGTSWRKE TVQLWPGPSG YSSLATLEGS MDGEEQAPQL YVLYEKGRNH YTESISVAKI SVYGTL
Positive Samples: Mouse liver, Rat liver; Cellular Location: Cell membrane, Cytoplasmic vesicle, Lumenal side, Lysosome lumen, Lysosome membrane, Peripheral membrane protein
靶标信息
NEU1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A. Mutations in NEU1 gene can lead to sialidosis.The protein encoded by this gene encodes the lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Acetylneuraminyl hydrolase; EC 3.2.1.18; exo-alpha-sialidase; FLJ93471; G9 sialidase; HLA-B-associated transcript 7; Lysosomal sialidase; N-acetyl-alpha-neuraminidase 1; sialidase 1; sialidase 1 (lysosomal sialidase); Sialidase-1
基因别名: AA407268; AA407316; Aglp; Apl; Bat-7; Bat7; G9; Map-2; NANH; NEU; Neu-1; NEU1; SIAL1
UniProt ID: (Human) Q99519, (Mouse) O35657
Entrez Gene ID: (Human) 4758, (Mouse) 18010, (Rat) 24591
