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NeoBiotechnologies
NEUROD2 (Neurogenic Differentiation 2) (Transcription Factor) Monoclonal Antibody (PCRP-NEUROD2-1G1)
产品信息
4761-MSM1-P0
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
PCRP-NEUROD2-1G1
抗原
Recombinant full-length human NEUROD2 protein
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Members of the myogenic determination family are basic helix-loop-helix (bHLH) proteins that can be separated into two classes, both of which work together to activate DNA transcription. Class A proteins include the ubiquitously expressed E-box binding factors, namely E2A, ITF-2 and HEB, while class B proteins, such as MyoD, myogenin and Neuro D (BETA2), are transiently expressed and exhibit a much more limited tissue distribution. Neuro D2 (neurogenic differentiation 2), also known as NDRF, NEUROD2 or bHLHa1, is a 382 amino acid nuclear protein that contains one bHLH domain and functions to induce neurogenic differentiation, playing an important role in the maintenance and determination of cell fate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLHa1; Class A basic helix-loop-helix protein 1; NDF2; NDR2; NDRF; NeuroD-related factor; NeuroD2; neurogenic basic-helix-loop-helix protein; neurogenic differentiation 2; Neurogenic differentiation factor 2
基因别名: BHLHA1; NDRF; NEUROD2
UniProt ID: (Human) Q15784
Entrez Gene ID: (Human) 4761
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein heterodimerization activity
E-box binding
basic helix-loop-helix transcription factor
behavioral fear response
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
nervous system development
associative learning
protein ubiquitination
cerebellar cortex development
positive regulation of synaptic plasticity
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
neuron development
positive regulation of calcium-mediated signaling
positive regulation of sequence-specific DNA binding transcription factor activity
cellular response to electrical stimulus
cellular response to calcium ion
positive regulation of synapse maturation
negative regulation of nucleic acid-templated transcription
negative regulation of synapse maturation
