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NFATC3 Antibody (PA5-36101) in IHC
International journal of molecular sciences 2021 -
Figure 3 Myocardial expression of calcineurin/NFAT and TRPC6: ( a ) the representative microphotographs of the myocardial expression of TRPC6/CaN/NFAT; the morphometric analysis of myocardial ( b ) TRPC6 (200 x ; scale bar, 100 mum), ( c ) CaN (200 x ), and ( d ) nuclear NFATc3 (400 x ; scale bar, 50 mum) IHC staining; and ( c ) the relative mRNA expression of ( e ) Trpc6 , ( f ) calcineurin A ( Ppp3ca ) an... View More
产品信息
PA5-36101
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 130-180 of human NFAT4
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553368
产品详细信息
This antibody detects endogenous protein at a molecular weight of 115 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: NF-AT4; NF-ATc3; NFAC3; NFATx; NFC3; nuclear factor of activated T-cells c3 isoform IE-Xa; Nuclear factor of activated T-cells, cytoplasmic 3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4; T-cell transcription factor NFAT4
基因别名: C80703; D8Ertd281e; NFAT4; NFATC3; NFATX
UniProt ID: (Human) Q12968
Entrez Gene ID: (Human) 4775, (Rat) 361400, (Mouse) 18021
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
protein binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
sequence-specific DNA binding
Rel homology transcription factor
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
inflammatory response
Fc-epsilon receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
patterning of blood vessels
response to hypoxia
blood vessel remodeling
regulation of transcription, DNA-templated
heart development
cardiac muscle hypertrophy in response to stress
myotube differentiation
myotube cell development
T cell differentiation
calcineurin-NFAT signaling cascade
cellular respiration
positive regulation of transcription, DNA-templated
thymus development
skeletal muscle fiber development
smooth muscle cell differentiation
muscle cell development
cellular response to calcium ion
cellular response to lithium ion
regulation of store-operated calcium entry
transcription, DNA-templated
