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产品信息
PA5-67842
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from human NFE2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2692183
产品详细信息
Predicted to react with Mouse and Rat samples.
靶标信息
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Leucine zipper protein NF-E2; nuclear factor (erythroid-derived 2), 45kD; nuclear factor (erythroid-derived 2), 45kDa; nuclear factor, erythroid derived 2; Nuclear factor, erythroid-derived 2 45 kDa subunit; p45 NF-E2; Transcription factor NF-E2 45 kDa subunit
基因别名: NF-E2; NF-E2/P45; NFE2; p45; p45nf-e2; p45NFE2
UniProt ID: (Human) Q16621, (Rat) Q6AYT2, (Mouse) Q07279
Entrez Gene ID: (Human) 4778, (Rat) 366998, (Mouse) 18022
nucleosome disassembly
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
multicellular organism development
blood coagulation
hemostasis
blood circulation
positive regulation of transcription, DNA-templated
cell-cell signaling
negative regulation of bone mineralization
negative regulation of syncytium formation by plasma membrane fusion
labyrinthine layer blood vessel development
positive regulation of peptidyl-lysine acetylation
