Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 5
NFIX Antibody (MA5-46983) in ICC/IF
Immunofluorescent analysis of NFIX in DIV10 rat E18 primary hippocampal neuron and glia cells. Cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: NFIX stained by NFIX monoclonal antibody (Product # MA5-46983) diluted at 1:250. Red: Tau, a cytoskeleton marker, stained by Tau antibody [GT287] diluted at 1:500.
产品信息
MA5-46983
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1269
抗原
Recombinant protein encompassing a sequence within the center region of human NFIX. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2938055
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, alpha-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: CCAAT-binding transcription factor; CCAAT-box-binding transcription factor; CTF; KIAA1439; NF-I/A; NF-I/B; NF-I/C; NF-I/X; NF1-A; NF1-B; NF1-C; NF1-X; NF1-X1 protein; NFI; NFI-A; NFI-B; NFI-C; NFIA; NFIB; NFIC; Nuclear factor 1 X-type; Nuclear factor 1/A; Nuclear factor 1/B; Nuclear factor 1/C; nuclear factor 1/X; Nuclear factor I/A; Nuclear factor I/B; Nuclear factor I/C; Nuclear factor I/X; nuclear factor I/X (CCAAT-binding transcription factor); TGGCA-binding protein
基因别名: CTF; MRSHSS; NF-I/X; NF1-X; NF1A; NFI-X; NFIX; SOTOS2
UniProt ID: (Human) Q14938, (Mouse) P70257
Entrez Gene ID: (Human) 4784, (Mouse) 18032, (Rat) 81524
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA-binding transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
DNA replication
transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
cerebellum development
cerebellar Purkinje cell layer development
cerebellar granule cell differentiation
astrocyte differentiation
