Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-49695
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Fusion protein corresponding to a region derived from 1-221 amino acids of human nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2635148
产品详细信息
The antibody detects endogenous level of total NFKBID protein.
靶标信息
May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes.I-kappa-BNS, the nuclear I-kappa-B-like protein encoded by Nfkbid, is required for the development of marginal zone and peritoneal B-1 B cells and additionally required for extrafollicular antibody responses to T-independent and -dependent immunogens.I-kappa-BNS has been identified as a member of the I-kappa-B family of NF-kappa-B inhibitors, which undergoes induction upon TCR signaling. I-kappa-BNS mediates both positive and negative gene regulation, depending on individual cell type and/or cytokine.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: I-kappa-B-delta; ikappaBdelta; IkappaBNS; IkB-delta; NF-kappa-B inhibitor delta; NFKB inhibitor delta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta; T-cell activation NFKB-like protein; TA-NFKBH
基因别名: IkappaBNS; IKBNS; NFKBID; TA-NFKBH
UniProt ID: (Human) Q8NI38
Entrez Gene ID: (Human) 84807
regulation of transcription from RNA polymerase II promoter
inflammatory response
negative regulation of NF-kappaB transcription factor activity
negative regulation of T cell differentiation in thymus
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of thymocyte apoptotic process
