Alomone Labs, LTD

NGF/proNGF Neutralizing Monoclonal Antibody (HAL06)

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实验方案
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说明书
实验方案
技术支持

产品信息

ALM-006-250UG

应用
建议稀释比
已发表文章

酶联免疫吸附实验 (ELISA)

2 µg/ml
-

中和实验 (Neu)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

HAL06

抗原

Highly purified 2.5S mouse NGF, Secreted
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 50 µL or 0.25 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is NTF3. proNGF is abundant in central nervous system tissues whereas mature NGF is undetectable, suggesting that proNGF may have a function distinct from its role as a precursor. Studies suggest that proNGF has apoptotic activity which contrast with other data demonstrating that proNGF has neurotrophic activity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Beta-nerve growth factor; Beta-NGF; Nerve growth factor; nerve growth factor (beta polypeptide); nerve growth factor, beta; nerve growth factor, beta subunit; proNGF

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基因别名: Beta-NGF; HSAN5; NGF; NGFB

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UniProt ID: (Human) P01138, (Mouse) P01139, (Rat) P25427

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Entrez Gene ID: (Human) 4803, (Mouse) 18049, (Rat) 310738

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功能
nerve growth factor receptor binding protein binding growth factor activity metalloendopeptidase inhibitor activity enzyme inhibitor activity receptor signaling protein activity receptor binding peptidase inhibitor activity molecular_function neurotrophic factor
参与通路
activation of MAPKK activity activation of cysteine-type endopeptidase activity involved in apoptotic process microtubule-based movement transmembrane receptor protein tyrosine kinase signaling pathway cell-cell signaling extrinsic apoptotic signaling pathway via death domain receptors positive regulation of gene expression nerve growth factor processing positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of neuron apoptotic process regulation of neuron differentiation positive regulation of Ras protein signal transduction neurotrophin TRK receptor signaling pathway phosphatidylinositol-mediated signaling neuron projection morphogenesis positive regulation of axonogenesis peripheral nervous system development memory positive regulation of cell proliferation adult locomotory behavior negative regulation of peptidase activity negative regulation of endopeptidase activity positive regulation of neuron projection development positive regulation of neuron maturation sensory perception of pain positive regulation of cell growth neuron projection development positive regulation of protein ubiquitination positive regulation of protein autophosphorylation intracellular signal transduction nerve growth factor signaling pathway positive regulation of neuron differentiation positive regulation of axon extension regulation of neurotransmitter secretion positive regulation of collateral sprouting positive regulation of sequence-specific DNA binding transcription factor activity regulation of release of sequestered calcium ion into cytosol positive regulation of neurotrophin TRK receptor signaling pathway neuron apoptotic process cellular response to acid chemical extrinsic apoptotic signaling pathway in absence of ligand positive regulation of stem cell proliferation negative regulation of type B pancreatic cell apoptotic process inflammatory response aging circadian rhythm response to radiation response to mechanical stimulus response to organic substance response to ozone response to organic cyclic compound response to lipopolysaccharide response to nicotine response to drug response to peptide hormone response to glucocorticoid response to electrical stimulus
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