Invitrogen

NKp46 (CD335) Polyclonal Antibody

NKp46 (CD335) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NKp46 (CD335) Antibody (PA5-79720) in IHC (P)

Immunohistochemical analysis of NCR1 in paraffin-embedded section of mouse lung tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1μg/mL rabbit anti-NCR1 antibody (Product # PA5-79720) overnight at 4°C. Biotinylated goat anti-rabbit IgG was used... View More

NKp46 (CD335) Antibody in Western Blot (WB)

NKp46 (CD335) Antibody in Immunocytochemistry (ICC/IF)

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产品信息

PA5-79720

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

0.5-1 µg/mL

免疫细胞化学 (ICC/IF)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

E. coli-derived human NCR1 recombinant protein (Position: Q22-R258).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 4mg trehalose

内含物

no preservative

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2746835

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

靶标信息

NKp46 (CD335, NCR1, ) is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. NKp46 consists of two Ig-like domains assembled to leukocyte immunoglobulin-like (LIR) and killer inhibitory receptors (KIR).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Low-dose IL-2 prevents murine chronic cardiac allograft rejection: Role for IL-2-induced T regulatory cells and exosomes with PD-L1 and CD73.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Ravichandran R,Itabashi Y,Fleming T,Bansal S,Bowen S,Poulson C,Bharat A,Bremner R,Smith M,Mohanakumar T

PA5-79720 was used in Immunohistochemistry (Paraffin), Western Blot to show that low-dose IL-2 delays rejection in a murine model of chronic cardiac allograft rejection and also induces graft-infiltrating Tregs and circulating exosomes with immunoregulatory molecules.

Thu Sep 01 00:00:00 UTC 2022

MITF induces escape from innate immunity in melanoma.

Journal of experimental & clinical cancer research : CR

Sánchez-Del-Campo L,Martí-Díaz R,Montenegro MF,González-Guerrero R,Hernández-Caselles T,Martínez-Barba E,Piñero-Madrona A,Cabezas-Herrera J,Goding CR,Rodríguez-López JN

PA5-79720 was used in Immunohistochemistry to examine the potential role of the lineage survival oncogene MITF to modulate the anti-melanoma immune response.

Wed Mar 31 00:00:00 UTC 2021

Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-immunotherapy in Multiple Solid Tumors.

ACS nano

Mei KC,Liao YP,Jiang J,Chiang M,Khazaieli M,Liu X,Wang X,Liu Q,Chang CH,Zhang X,Li J,Ji Y,Melano B,Telesca D,Xia T,Meng H,Nel AE

PA5-79720 was used in Immunohistochemistry to support the use of encapsulated MTO delivery for chemo-immunotherapy, with the possibility to boost the immune response by codelivery of an IDO-1 pathway inhibitor.

Tue Oct 27 00:00:00 UTC 2020

Topographical Distribution and Spatial Interactions of Innate and Semi-Innate Immune Cells in Pancreatic and Other Periampullary Adenocarcinoma.

Frontiers in immunology

Lundgren S,Micke P,Elebro J,Heby M,Hrynchyk I,Nodin B,Leandersson K,Mezheyeuski A,Jirström K

PA5-79720 was used in Immunohistochemistry to comprehensively map the abundance, topographic distribution and spatial interaction of innate and innate-like immune cells in the tumor microenvironment of periampullary adenocarcinoma.

Wed May 19 00:00:00 UTC 2021

Topographical Distribution and Spatial Interactions of Innate and Semi-Innate Immune Cells in Pancreatic and Other Periampullary Adenocarcinoma.

Frontiers in immunology

Lundgren S,Micke P,Elebro J,Heby M,Hrynchyk I,Nodin B,Leandersson K,Mezheyeuski A,Jirström K

Wed May 19 00:00:00 UTC 2021

生物信息学

蛋白别名: 1-Mar; Activating receptor 1; CD335; hNKp46; Ly-94; Lymphocyte antigen 94; Lymphocyte antigen 94 homolog; lymphocyte antigen 94 homolog (activating NK-receptor; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); mAR-1; MAR1 (mouse activating receptor 1); mNKp46; Natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; natural killer cell receptor; NK cell-activating receptor; NK receptor KILR-1; NK-p46; NK-p46); NKACTR; rAR-1; rat-activating receptor 1

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基因别名: Ar1; CD335; KILR-1; Kilr1; LY94; NCR1; NK-p46; NKP46

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UniProt ID: (Human) O76036, (Rat) Q9Z0H5, (Mouse) Q8C567

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Entrez Gene ID: (Human) 9437, (Rat) 117547, (Mouse) 17086

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功能

receptor signaling protein activity immunoglobulin receptor superfamily

参与通路

cellular defense response signal transduction natural killer cell activation regulation of natural killer cell mediated cytotoxicity regulation of immune response detection of virus defense response to virus