Invitrogen

NLGN3 Polyclonal Antibody

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NLGN3 Antibody (PA5-18849) in WB

Western blot analysis of NLGN3 using NLGN3 Polyclonal Antibody (Product # PA5-18849) (0.1 µg/mL) in staining of Human Brain (Amygdala) lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

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产品信息

PA5-18849

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.05-0.2 µg/mL

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产品规格

种属反应

Human

已发表种属

Mouse

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide sequence (RKDKRRQEPLRQPS) corresponding to the internal amino acids of NLGN3 (aa 732-746).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Ammonium sulfate precipitation

保存液

TBS, pH 7.3, with 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_10982837

产品详细信息

This antibody is predicted to react with canine, mouse and rat based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.

靶标信息

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

SLC13A5/sodium-citrate co-transporter overexpression causes disrupted white matter integrity and an autistic-like phenotype.

Brain communications

Rigby MJ,Orefice NS,Lawton AJ,Ma M,Shapiro SL,Yi SY,Dieterich IA,Frelka A,Miles HN,Pearce RA,Yu JPJ,Li L,Denu JM,Puglielli L

PA5-18849 was used in Western Blot to test the hypothesis that modulating the intracellular flux of citrate through overexpression of SLC13A5, the plasma membrane sodium/citrate symporter, would result in an autistic-like phenotype in a mouse model.

Tue Feb 01 00:00:00 UTC 2022

Increased expression of SLC25A1/CIC causes an autistic-like phenotype with altered neuron morphology.

Brain : a journal of neurology

Rigby MJ,Orefice NS,Lawton AJ,Ma M,Shapiro SL,Yi SY,Dieterich IA,Frelka A,Miles HN,Pearce RA,Yu JPJ,Li L,Denu JM,Puglielli L

PA5-18849 was used in Western Blot to reinforce the connection between aberrant cytosolic-to-endoplasmic reticulum acetyl-CoA flux and the development of an autistic-like phenotype.