Invitrogen

NLGN3 Monoclonal Antibody (566209)

NLGN3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NLGN3 Antibody (MA5-24253) in IHC (P)

Immunohistochemical analysis of NLGN3 in immersion fixed paraffin-embedded sections of human brain (cerebellum). Samples were incubated in NLGN3 monoclonal antibody (Product # MA5-24253) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary ... View More

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产品信息

MA5-24253

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

8-25 µg/mL

免疫细胞化学 (ICC/IF)

8-25 µg/mL

免疫沉淀 (IP)

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产品规格

种属反应

Human

已发表种属

Mouse

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

566209

抗原

Mouse myeloma cell line NS0-derived recombinant human Neuroligin 3 Gln38-Leu709

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.5 mg/mL

纯化类型

Protein A/G

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2576897

产品详细信息

100% cross-reactivity with recombinant human (rh) Neuroligin 3 variant 2 and recombinant rat Neuroligin 3 variant 2 and no cross-reactivity with rhNeuroligin 1 variant 2, rhNeuroligin 2, rhNeuroligin 4, recombinant rat Neuroligin 1, 1 variant 2, 2 variant 2, or 3 variant 4 is observed.

Reconstitute at 0.5 mg/mL in sterile PBS.

靶标信息

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Synaptic protein interaction networks encode experience by assuming stimulus-specific and brain-region-specific states.

Cell reports

Lautz JD,Tsegay KB,Zhu Z,Gniffke EP,Welsh JP,Smith SEP

MA5-24253 was used in Immunoprecipitation to conclude that although the PIN of the glutamatergic post-synapse is expressed widely throughout the brain, its activity-dependent dynamics show remarkable stimulus-specific and brain-region-specific diversity.