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产品信息
MA5-42647
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1H1T3
抗原
A synthetic peptide corresponding to a sequence within amino acids 800-900 of human NMDAR1 (Q05586).
偶联物
形式
Liquid
浓度
0.46 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2911788
产品详细信息
Positive test controls include: Mouse brain. The target is usually found in the following locations: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, postsynaptic density, synapse.
Immunogen sequence: SRSNAPATLT FENMAGVFML VAGGIVAGIF LIFIEIAYKR HKDARRKQMQ LAFAAVNVWR KNLQDRKSGR AEPDPKKKAT FRAITSTLAS SFKRRRSSKD T
靶标信息
NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GluN1; Glun1r; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; RP11-350O14.1
基因别名: GluN1; GluRdelta1; Glurz1; GluRzeta1; Grin1; M100174; NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174
UniProt ID: (Mouse) P35438
Entrez Gene ID: (Mouse) 14810
receptor activity
ionotropic glutamate receptor activity
NMDA glutamate receptor activity
receptor binding
ion channel activity
extracellular-glutamate-gated ion channel activity
cation channel activity
calcium channel activity
calcium ion binding
protein binding
calmodulin binding
glycine binding
glutamate binding
enzyme binding
voltage-gated cation channel activity
glutamate receptor binding
neurotransmitter binding
protein heterodimerization activity
protein dimerization activity
transmembrane signal receptor
conditioned taste aversion
startle response
suckling behavior
response to amphetamine
transport
ion transport
cation transport
calcium ion transport
cellular calcium ion homeostasis
chemical synaptic transmission
respiratory gaseous exchange
learning or memory
learning
memory
long-term memory
associative learning
adult locomotory behavior
olfactory learning
visual learning
regulation of cell communication
positive regulation of cell death
propylene metabolic process
sensory perception of pain
pons maturation
cerebral cortex development
ion transmembrane transport
regulation of ion transmembrane transport
social behavior
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of membrane potential
positive regulation of apoptotic process
response to morphine
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
regulation of respiratory gaseous exchange
response to ethanol
positive regulation of transcription from RNA polymerase II promoter
regulation of synaptic plasticity
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
rhythmic process
regulation of dendrite morphogenesis
regulation of axonogenesis
neuromuscular process
protein tetramerization
regulation of synapse assembly
calcium ion homeostasis
excitatory postsynaptic potential
prepulse inhibition
male mating behavior
calcium ion transmembrane transport
cation transmembrane transport
positive regulation of excitatory postsynaptic potential
