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NMDAR1 Antibody (710020) in IHC (P)
Immunohistochemistry analysis of NMDAR1 showing staining in the cytoplasm of paraffin-embedded human brain tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, wa... View More
Product Details
710020
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Clone
1HCLC
Immunogen
Recombinant NMDA Receptor 1 protein corresponding to amino acids 834-938
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2532531
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
Target Information
NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GluN1; Glun1r; glutamate [NMDA] receptor subunit zeta 1; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; RP11-350O14.1
Gene Aliases: GluN1; GluRdelta1; Glurz1; GluRzeta1; GRIN1; M100174; MRD8; NMD-R1; NMDA1; Nmdar; NMDAR1; NR1; Rgsc174
UniProt ID: (Human) Q05586, (Rat) P35439, (Mouse) P35438
Entrez Gene ID: (Human) 2902, (Rat) 24408, (Mouse) 14810
NMDA glutamate receptor activity
Ras guanyl-nucleotide exchange factor activity
extracellular-glutamate-gated ion channel activity
calcium channel activity
calcium ion binding
protein binding
calmodulin binding
glycine binding
glutamate binding
enzyme binding
voltage-gated cation channel activity
glutamate receptor binding
neurotransmitter binding
protein heterodimerization activity
ionotropic glutamate receptor activity
receptor binding
cation channel activity
protein dimerization activity
receptor activity
ion channel activity
transmembrane signal receptor
MAPK cascade
conditioned taste aversion
suckling behavior
response to amphetamine
cation transport
cellular calcium ion homeostasis
chemical synaptic transmission
respiratory gaseous exchange
long-term memory
adult locomotory behavior
olfactory learning
visual learning
propylene metabolic process
sensory perception of pain
pons maturation
cerebral cortex development
regulation of ion transmembrane transport
social behavior
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of membrane potential
positive regulation of apoptotic process
response to morphine
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
regulation of respiratory gaseous exchange
response to ethanol
positive regulation of transcription from RNA polymerase II promoter
ephrin receptor signaling pathway
regulation of long-term neuronal synaptic plasticity
rhythmic process
regulation of dendrite morphogenesis
regulation of axonogenesis
protein tetramerization
response to calcium ion
regulation of synapse assembly
calcium ion homeostasis
excitatory postsynaptic potential
prepulse inhibition
male mating behavior
response to fungicide
calcium ion transmembrane transport
cellular response to manganese ion
positive regulation of excitatory postsynaptic potential
startle response
calcium ion transport
learning or memory
learning
memory
associative learning
regulation of cell communication
positive regulation of cell death
response to organic cyclic compound
response to amine
ion transmembrane transport
regulation of neuron apoptotic process
regulation of synaptic plasticity
regulation of neuronal synaptic plasticity
neuromuscular process
transport
ion transport
cation transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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