Invitrogen

NMDAR2C Polyclonal Antibody

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NMDAR2C Antibody (OPA1-04020) in WB

Western blot of NMDAR2C in rat cerebellar lysate (10 µg) using a NMDAR2C polyclonal antibody (Product # OPA1-04020), showing specific immunolabeling of a ~140 kDa band corresponding to the NR2C subunit of the NMDA receptor.

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产品信息

OPA1-04020

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

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免疫沉淀 (IP)

3 µL / 200 µg lysate

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Fusion protein from the N-terminal region of the NR2C subunit of rat GRIN2C

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.2 mg/mL

纯化类型

Affinity chromatography

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2112587

产品详细信息

This antibody detects predominantly the NR2C isoform but may show low level cross-reactivity with the NR2A and NR2B isoforms.

In Western blot, this antibody detects a ~140 kDa protein representing NR2C in rat brain homogenate. Faint bands representing the NR2A and NR2B isoforms at 180 KDa may also be observed. Immunohistochemical staining in rat brain with OPA1-04020 yields a pattern consistent with plasma membrane staining.

Reconstitute with 50 µL of PBS.

靶标信息

The NMDA Receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimers, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of th NMDAR2 (NR2 A-D) subunits.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Reconstitution of synaptic Ion channels from rodent and human brain in Xenopus oocytes: a biochemical and electrophysiological characterization.

Journal of neurochemistry

Mazzo F,Zwart R,Serratto GM,Gardinier KM,Porter W,Reel J,Maraula G,Sher E

Published figure using NMDAR2C polyclonal antibody (Product # OPA1-04020) in Western Blot

Mon Aug 01 00:00:00 UTC 2016

Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Piña-Crespo JC,Talantova M,Micu I,States B,Chen HS,Tu S,Nakanishi N,Tong G,Zhang D,Heinemann SF,Zamponi GW,Stys PK,Lipton SA

OPA1-04020 was used in western blot to investigate the role of NR1/NR3 NMDA receptor subunits for excitatory glycine responses of CNS myelin

Wed Aug 25 00:00:00 UTC 2010

Glutamate signaling proteins and tyrosine hydroxylase in the locus coeruleus of alcoholics.

Journal of psychiatric research

Karolewicz B,Johnson L,Szebeni K,Stockmeier CA,Ordway GA

OPA1-04020 was used in western blot to investigate the effect of glutamate signaling proteins and tyrosine hydroxylase on alcoholism

Tue Apr 01 00:00:00 UTC 2008

Elevated levels of the NR2C subunit of the NMDA receptor in the locus coeruleus in depression.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Karolewicz B,Stockmeier CA,Ordway GA

OPA1-04020 was used in western blot to investigate the expression of the NMDA receptor NR2C subunit in the locus coeruleus in major depression patients

Mon Aug 01 00:00:00 UTC 2005

生物信息学

蛋白别名: GluN2C; GluRepsilon3; Glutamate [NMDA] receptor subunit epsilon-3; glutamate receptor; Glutamate receptor ionotropic, NMDA 2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C; glutamate receptor, ionotropic, NMDA2C; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; NMDA glutamate receptor; NMDAR2C; NR2

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基因别名: GluN2C; GRIN2C; NMDAR2C; NR2C

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UniProt ID: (Human) Q14957, (Mouse) Q01098, (Rat) Q00961

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Entrez Gene ID: (Human) 2905, (Mouse) 14813, (Rat) 24411

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功能