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产品信息
PA5-95243
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human NMDAR2C recombinant protein (Position: Q43-Q242).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2807047
产品详细信息
Human NMDAR2C shares 93% and 92.5% amino acid (aa) sequence identity with mouse and rat NMDAR2C, respectively.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
The NMDA Receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimers, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of th NMDAR2 (NR2 A-D) subunits.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GluN2C; Glutamate [NMDA] receptor subunit epsilon-3; glutamate receptor; Glutamate receptor ionotropic, NMDA 2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C; glutamate receptor, ionotropic, NMDA2C; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; NMDA glutamate receptor; NMDAR2C; NR2
基因别名: GluN2C; GRIN2C; NMDAR2C; NR2C
UniProt ID: (Human) Q14957, (Rat) Q00961
Entrez Gene ID: (Human) 2905, (Rat) 24411
MAPK cascade
transport
glutamate receptor signaling pathway
chemical synaptic transmission
protein localization
response to wounding
directional locomotion
ionotropic glutamate receptor signaling pathway
negative regulation of protein catabolic process
positive regulation of GTPase activity
neuromuscular process controlling balance
excitatory postsynaptic potential
cation transmembrane transport
startle response
ion transmembrane transport
synaptic transmission, glutamatergic
regulation of membrane potential
