Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 3
NMDAR2C (GRIN2C) (extracellular) Antibody (AGC-018-200UL) in IHC (P)
Expression of NMDAR2C in rat pancreas - Immunohistochemical staining rat pancreas paraffin-embedded sections using Anti-NMDAR2C (GRIN2C) (extracellular) Antibody (#AGC-018), (1:100) followed by goat- Anti-rabbit-AlexaFluor-594 (red) secondary Antibody . Staining is present in endocrine cells of the Isles of Langerhans. Hoechst 33342 is used as the counterstain (blue).
产品信息
AGC-018-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)RHRLWEMVGRWDH, corresponding to amino acid residues 365-377 of rat NMDAR2C, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The NMDA Receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimers, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of th NMDAR2 (NR2 A-D) subunits.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: GluN2C; GluRepsilon3; Glutamate [NMDA] receptor subunit epsilon-3; glutamate receptor; Glutamate receptor ionotropic, NMDA 2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C; glutamate receptor, ionotropic, NMDA2C; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; NMDA glutamate receptor; NMDAR2C; NR2
基因别名: GluN2C; GRIN2C; NMDAR2C; NR2C
UniProt ID: (Human) Q14957, (Mouse) Q01098, (Rat) Q00961
Entrez Gene ID: (Human) 2905, (Mouse) 14813, (Rat) 24411
NMDA glutamate receptor activity
Ras guanyl-nucleotide exchange factor activity
extracellular-glutamate-gated ion channel activity
cation channel activity
protein binding
PDZ domain binding
protein N-terminus binding
receptor activity
ionotropic glutamate receptor activity
ion channel activity
transmembrane signal receptor
MAPK cascade
transport
glutamate receptor signaling pathway
chemical synaptic transmission
protein localization
response to wounding
directional locomotion
ionotropic glutamate receptor signaling pathway
negative regulation of protein catabolic process
positive regulation of GTPase activity
neuromuscular process controlling balance
excitatory postsynaptic potential
cation transmembrane transport
startle response
ion transport
ion transmembrane transport
synaptic transmission, glutamatergic
regulation of membrane potential
