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NME5 Antibody (PA5-100641) in ICC/IF
Immunocytochemistry analysis of NME5 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with NME5 polyclonal antibody (Product # PA5-100641) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-100641
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NME5(Accession P56597), corresponding to amino acid residues T174-Y212.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850147
产品详细信息
Antibody detects endogenous levels of total NME5.
靶标信息
Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3'-5' exonuclease NME5; expressed in non-metastatic cells 5; Inhibitor of p53-induced apoptosis-beta; IPIA-beta; NDK-H 5; NDP kinase homolog 5; nm23-H5; nm23-M5; NME/NM23 family member 5; non-metastatic cells 5 protein expressed in; non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase); Nucleoside diphosphate kinase homolog 5; radial spoke 23 homolog; Rsph23; Testis-specific nm23 homolog
基因别名: 1700019D05Rik; NM23-H5; Nm23-M5; NM23H5; NME5; RSPH23
UniProt ID: (Human) P56597, (Mouse) Q99MH5
Entrez Gene ID: (Human) 8382, (Mouse) 75533, (Rat) 688903
epithelial cilium movement
nucleoside diphosphate phosphorylation
GTP biosynthetic process
UTP biosynthetic process
CTP biosynthetic process
spermatogenesis
spermatid development
nucleoside metabolic process
ventricular system development
cilium assembly
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
response to reactive oxygen species
multicellular organism development
cell differentiation
spermatid differentiation
