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产品信息
PA5-66236
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2663913
产品详细信息
Immunogen sequence: GLVRCFSTLQW LFRLDISFES QHILLRGDKT SRDMWATGSL PDFPAAAKFL GFRQRCIPRS LCLSECPLEP PSLTRLCATL KDCPGPLELQ LSCEFLSDQ
Highest antigen sequence identity to the following orthologs - mouse 55%, rat 50%.
靶标信息
NOD4 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD4 contains a CARD-like domain, a central NOD domain and a large LRR region. NOD4, an IFN-gamma-inducible nuclear protein, plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. As a key negative regulator of NF-kappa-B and type I interferon signaling, NOD4 may be a useful target for manipulating immune responses against infectious or inflammation-associated diseases, including cancer.
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生物信息学
蛋白别名: Caterpiller protein 16.1; CLR16.1; NLR family, CARD domain containing 5; NOD-like receptor C5; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5; nucleotide-binding oligomerization domains 27; Protein NLRC5
基因别名: CLR16.1; NLRC5; NOD27; NOD4
UniProt ID: (Human) B5MEF1
Entrez Gene ID: (Human) 84166
negative regulation of NF-kappaB transcription factor activity
negative regulation of type I interferon production
regulation of kinase activity
innate immune response
positive regulation of MHC class I biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
positive regulation of interferon-gamma-mediated signaling pathway
negative regulation of type I interferon-mediated signaling pathway
positive regulation of type I interferon-mediated signaling pathway
