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This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: H/ACA ribonucleoprotein complex subunit 3; homolog of yeast Nop10p; NOP10 ribonucleoprotein homolog; Nucleolar protein 10; Nucleolar protein family A member 3; nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs); snoRNP protein NOP10
基因别名: DKCB1; NOLA3; NOP10; NOP10P
UniProt ID: (Human) Q9NPE3
Entrez Gene ID: (Human) 55505