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产品信息
PA5-27372
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 1 and 139 of Human NR4A3
偶联物
形式
Liquid
浓度
0.34 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2544848
产品详细信息
Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7.
Predicted reactivity: Mouse (80%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
NOR-1, a NR4 nerve growth factor-like receptor, has been shown to affect neuronal development, T-cell apoptosis, and cancer development. NOR-1 binds to NBRE (NGFI-B response element) and regulates the pro-opiomelanocortin (POMC) gene. NOR-1 is induced rapidly but transiently by a variety of stimuli. Downregulation of NOR-1 and other NGFI-B family members is correlated with drug addiction-prone behavior of Lewis rats. Three human protein isoforms have been documented: NOR-1, NOR-1beta, and NOR-1 3' variant.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: chondrosarcoma, extraskeletal myxoid, fused to EWS; Mitogen-induced nuclear orphan receptor; Neuron-derived orphan receptor 1; Nuclear hormone receptor NOR-1; Nuclear receptor subfamily 4 group A member 3; nuclear receptor subfamily 4, group A, member 3; TEC receptor; translocated in extraskeletal chondrosarcoma
基因别名: CHN; CSMF; MINOR; NOR1; NR4A3; TEC
UniProt ID: (Human) Q4VXA8
Entrez Gene ID: (Human) 8013
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription coactivator binding
DNA binding
steroid hormone receptor activity
thyroid hormone receptor activity
protein binding
zinc ion binding
protein kinase binding
histone acetyltransferase binding
glucocorticoid receptor binding
protein homodimerization activity
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
mesoderm formation
transcription initiation from RNA polymerase II promoter
gastrulation
axon guidance
biological_process
pyruvate oxidation
positive regulation of cardiac muscle hypertrophy
positive regulation of glucose transport
hippocampus development
intracellular receptor signaling pathway
adult behavior
organ regeneration
positive regulation of mast cell cytokine production
common myeloid progenitor cell proliferation
positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway
response to hydrogen peroxide
mast cell degranulation
steroid hormone mediated signaling pathway
negative regulation of neuron apoptotic process
cellular response to leptin stimulus
cellular respiration
fat cell differentiation
positive regulation of cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fatty acid oxidation
regulation of smooth muscle cell proliferation
positive regulation of smooth muscle cell proliferation
semicircular canal morphogenesis
positive regulation of epithelial cell proliferation
neuromuscular process controlling balance
vestibular reflex
regulation of type B pancreatic cell proliferation
cellular response to corticotropin-releasing hormone stimulus
cellular response to catecholamine stimulus
energy homeostasis
positive regulation of monocyte aggregation
negative regulation of hydrogen peroxide-induced neuron death
positive regulation of leukocyte apoptotic process
positive regulation of feeding behavior
regulation of energy homeostasis
