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NOR-1 Antibody (MA5-26704) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human breast tissue. To expose target proteins, 1 mM EDTA in 10mM Tris, pH8.0 was used. Following antigen retrieval, tissues were probed with a NR4A3 monoclonal antibody (Product # MA5-26704) at a dilution of 1:150.
Product Details
MA5-26704
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5C2
Immunogen
Human recombinant protein fragment corresponding to amino acids 332-626 of NR4A3 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2724853
Target Information
NOR-1, a NR4 nerve growth factor-like receptor, has been shown to affect neuronal development, T-cell apoptosis, and cancer development. NOR-1 binds to NBRE (NGFI-B response element) and regulates the pro-opiomelanocortin (POMC) gene. NOR-1 is induced rapidly but transiently by a variety of stimuli. Downregulation of NOR-1 and other NGFI-B family members is correlated with drug addiction-prone behavior of Lewis rats. Three human protein isoforms have been documented: NOR-1, NOR-1beta, and NOR-1 3' variant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chondrosarcoma, extraskeletal myxoid, fused to EWS; Mitogen-induced nuclear orphan receptor; Neuron-derived orphan receptor 1; Nuclear hormone receptor NOR-1; Nuclear receptor subfamily 4 group A member 3; nuclear receptor subfamily 4, group A, member 3; TEC receptor; translocated in extraskeletal chondrosarcoma
Gene Aliases: CHN; CSMF; MINOR; NOR1; NR4A3; TEC
UniProt ID: (Human) Q4VXA8
Entrez Gene ID: (Human) 8013
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription coactivator binding
DNA binding
steroid hormone receptor activity
thyroid hormone receptor activity
protein binding
zinc ion binding
protein kinase binding
histone acetyltransferase binding
glucocorticoid receptor binding
protein homodimerization activity
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
mesoderm formation
transcription initiation from RNA polymerase II promoter
gastrulation
axon guidance
biological_process
pyruvate oxidation
positive regulation of cardiac muscle hypertrophy
positive regulation of glucose transport
hippocampus development
intracellular receptor signaling pathway
adult behavior
organ regeneration
positive regulation of mast cell cytokine production
common myeloid progenitor cell proliferation
positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway
response to hydrogen peroxide
mast cell degranulation
steroid hormone mediated signaling pathway
negative regulation of neuron apoptotic process
cellular response to leptin stimulus
cellular respiration
fat cell differentiation
positive regulation of cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fatty acid oxidation
regulation of smooth muscle cell proliferation
positive regulation of smooth muscle cell proliferation
semicircular canal morphogenesis
positive regulation of epithelial cell proliferation
neuromuscular process controlling balance
vestibular reflex
regulation of type B pancreatic cell proliferation
cellular response to corticotropin-releasing hormone stimulus
cellular response to catecholamine stimulus
energy homeostasis
positive regulation of monocyte aggregation
negative regulation of hydrogen peroxide-induced neuron death
positive regulation of leukocyte apoptotic process
positive regulation of feeding behavior
regulation of energy homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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