Invitrogen

NOTCH2 (Cleaved Ala1734) Polyclonal Antibody

NOTCH2 (Cleaved Ala1734) Antibody in Western Blot (WB)

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NOTCH2 (Cleaved Ala1734) Antibody (PA5-37433) in WB

Western blot analysis of NOTCH2 (Cleaved Ala1734) in Lane 1: MEF whole cell lysate (40 µg), Lane 2: C6 whole cell lysate (40 µg), Lane 3: A549 whole cell lysate (40 µg), Lane 4: HepG2 whole cell lysate (40 µg), Lane 5: U-87MG whole cell lysate (40 µg). Samples were incubated with NOTCH2 (Cleaved Ala1734) polyclonal antibody (Product # PA5-37433) at a dilution of 1:500.

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产品信息

PA5-37433

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to amino acids 1734-1800 of human Notch 2

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2554057

产品详细信息

This antibody detects endogenous protein at a molecular weight of 85 and 110 kDa.

Purity is >95% by SDS-PAGE.

靶标信息

The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. To date, four Notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The Notch genes are expressed in a variety of tissues in both the embryonic and adult organism, suggesting that the genes are involved in multiple signaling pathways. The Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged2 and Delta. Jagged can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

MFAP5 facilitates the aggressiveness of intrahepatic Cholangiocarcinoma by activating the Notch1 signaling pathway.

Journal of experimental & clinical cancer research : CR

Li JH,Zhu XX,Li FX,Huang CS,Huang XT,Wang JQ,Gao ZX,Li SJ,Xu QC,Zhao W,Yin XY

PA5-37433 was used in Western Blotting to show the aggressiveness of intrahepatic cholangiocarcinoma is mediated by microfibrillar-associated protein 5 activation of the Notch1 signaling pathway.