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NOV Antibody (H00004856-B01P) in WB
Western Blot analysis of NOV expression in transfected 293T cell line (H00004856-T01) by NOV MaxPab polyclonal antibody.
Lane 1: NOV transfected lysate(39.27 KDa).
Lane 2: Non-transfected lysate.
Lane 1: NOV transfected lysate(39.27 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00004856-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NOV (AAH15028.1, 1 a.a. approximately 357 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MQSVQSTSFC LRKQCLCLTF LLLHLLGQVA ATQRCPPQCP GRCPATPPTC APGVRAVLDG CSCCLVCARQ RGESCSDLEP CDESSGLYCD RSADPSKQTG ICTAVEGDNC VFDGVIYRSG EKFQPSCKFQ CTCRDGQIGC VPRCQLDVLL PEPNCPAPRK VEVPGECCEK WICGPDEEDS LGGLTLAAYR PEATLGVEVS DSSVNCIEQT TEWTACSKSC GMGFSTRVTN RNRQCEMLKQ TRLCMVRPCE QEPEQPTDKK GKKCLRTKKS LKAIHLQFKN CTSLHTYKPR FCGVCSDGRC CTPHNTKTIQ AEFQCSPGQI VKKPVMVIGT CTCHTNCPKN NEAFLQELEL KTTRGKM
靶标信息
NOV is a member of the CCN family of secreted, cysteine-rich regulatory proteins. The full-length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm's tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorigenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell-surface integrins, and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CCN family member 3; Cellular communication network factor 3; IBP-9; IGF-binding protein 9; Insulin-like growth factor-binding protein 9; Nephro blastoma-overexpressed gene protein homolog; nephroblastoma-overexpressed gene protein homolog; NovH; Protein NOV homolog
基因别名: CCN3; IBP-9; IGFBP-9; IGFBP9; NOV; NOVH
UniProt ID: (Human) P48745
Entrez Gene ID: (Human) 4856
angiogenesis
chondrocyte differentiation
cell-cell signaling
regulation of gene expression
fibroblast migration
negative regulation of myotube differentiation
smooth muscle cell migration
negative regulation of cell growth
cell adhesion mediated by integrin
endothelial cell chemotaxis
negative regulation of NF-kappaB import into nucleus
type B pancreatic cell proliferation
positive regulation of Notch signaling pathway
negative regulation of insulin secretion
smooth muscle cell proliferation
negative regulation of inflammatory response
cell chemotaxis
negative regulation of SMAD protein import into nucleus
negative regulation of cell death
hematopoietic stem cell homeostasis
endothelial cell-cell adhesion
negative regulation of monocyte chemotaxis
negative regulation of chondrocyte proliferation
negative regulation of sensory perception of pain
bone regeneration
