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NOX2 Antibody (PA5-120443) in IHC (P)
Immunohistochemistry analysis of NOX2 in paraffin-embedded rat bone marrow. Samples were incubated with NOX2 Polyclonal antibody (Product # PA5-120443) using a dilution of 1:200 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-120443
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 385-570 of human NOX2/gp91phox (NP_0003882)
偶联物
形式
Liquid
浓度
0.95 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914015
产品详细信息
Positive test controls include: U-87MG, HL-60, Mouse spleen. The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein.
Immunogen sequence: IAVDGPFGTA SEDVFSYEVV MLVGAGIGVT PFASILKSVW YKYCNNATNL KLKKIYFYWL CRDTHAFEWF ADLLQLLESQ MQERNNAGFL SYNIYLTGWD ESQANHFAVH HDEEKDVITG LKQKTLYGRP NWDNEFKTIA SQHPNTRIGV FLCGPEALAE TLSKQSISNS ESGPRGVHFI FNKENF
靶标信息
Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase complex expresses in phagocytes, neuroepithelial bodies, vascular smooth muscle cells, and endothelial cells. It includes a membrane bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. Mox1 and gp91 contain identical C-terminal sequence identity, yet possess distinct expression patterns. gp91-phox expresses in eosinophils, neutrophils, monocytes, and B-lymphocytes, whereas Mox1 is predominantly detected in the colon, with low expression in the uterus and prostate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CGD91-phox; Cytochrome b(558) subunit beta; cytochrome b-245 beta polypeptide; Cytochrome b-245 heavy chain; cytochrome b-245, beta polypeptide; Cytochrome b558 subunit beta; endothelial type gp91-phox; GP91 PHOX; gp91-1; gp91-phox; GP911; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; p22 phagocyte B-cytochrome; p91PHOX; Superoxide-generating NADPH oxidase heavy chain subunit
基因别名: AMCBX2; C88302; CGD; CGD91-phox; CYBB; Cyd; GP91-1; GP91-PHOX; GP91PHOX; IMD34; NOX2; p91-PHOX
UniProt ID: (Human) P04839, (Mouse) Q61093
Entrez Gene ID: (Human) 1536, (Rat) 66021, (Mouse) 13058
voltage-gated ion channel activity
protein binding
electron carrier activity
superoxide-generating NADPH oxidase activity
heme binding
metal ion binding
protein heterodimerization activity
flavin adenine dinucleotide binding
NAD(P)H oxidase activity
N-ethylmaleimide reductase activity
oxidoreductase activity
reduced coenzyme F420 dehydrogenase activity
sulfur oxygenase reductase activity
malolactic enzyme activity
NADPH:sulfur oxidoreductase activity
epoxyqueuosine reductase activity
oxidase
response to reactive oxygen species
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
superoxide metabolic process
ion transport
inflammatory response
regulation of ion transmembrane transport
superoxide anion generation
innate immune response
cell redox homeostasis
respiratory burst
vascular endothelial growth factor receptor signaling pathway
hydrogen peroxide biosynthetic process
oxidation-reduction process
response to nutrient
response to drug
transport
