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产品信息
PA5-19977
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to 17 amino acids at the amino terminus of mouse Noxa.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11154096
产品详细信息
A suggested positive control is human stomach tissue lysate.
PA5-19977 can be used with blocking peptide PEP-0305.
靶标信息
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: adult T cell leukemia-derived PMA-responsive; Immediate-early-response protein APR; Phorbol-12-myristate-13-acetate-induced protein 1; PMA-ind; PMA-induced protein 1; Protein Noxa
基因别名: APR; NOXA; PMAIP1
UniProt ID: (Human) Q13794, (Mouse) Q9JM54, (Rat) Q5U777
Entrez Gene ID: (Human) 5366, (Mouse) 58801, (Rat) 492821
release of cytochrome c from mitochondria
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to DNA damage stimulus
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
response to X-ray
negative regulation of mitochondrial membrane potential
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
T cell homeostasis
positive regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of neuron apoptotic process
negative regulation of fibroblast proliferation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
proteasomal protein catabolic process
positive regulation of glucose metabolic process
positive regulation of protein oligomerization
cellular response to glucose starvation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to dsRNA
regulation of mitochondrial membrane permeability
defense response to virus
cellular response to hypoxia
reactive oxygen species metabolic process
positive regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
