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NPR1 Antibody (PA5-71876) in IHC (P)
Immunohistochemistry analysis of NPR1 in formalin fixed and paraffin embedded mouse duodenum tissue. Samples were incubated with NPR1 polyclonal antibody (Product # PA5-71876) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
产品信息
PA5-71876
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 198-226 amino acids of mouse Npr1
偶联物
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2717730
靶标信息
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms. The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A and type B. Also see NPR3, which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides and BNP, respectively).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ANP-A; ANPR-A; Atrial natriuretic peptide receptor 1; Atrial natriuretic peptide receptor type A; GC-A; Guanylate cyclase A; guanylyl cyclase-A; Nppa receptor
基因别名: AI893888; GC-A; NPR-A; Npr1; NPRA; Pndr
UniProt ID: (Mouse) P18293
Entrez Gene ID: (Mouse) 18160
nucleotide binding
guanylate cyclase activity
protein kinase activity
ATP binding
GTP binding
transferase activity, transferring phosphorus-containing groups
lyase activity
phosphorus-oxygen lyase activity
natriuretic peptide receptor activity
peptide hormone binding
protein kinase binding
hormone binding
guanylate cyclase
cGMP biosynthetic process
protein phosphorylation
cell surface receptor signaling pathway
receptor guanylyl cyclase signaling pathway
regulation of blood pressure
cyclic nucleotide biosynthetic process
positive regulation of cGMP biosynthetic process
intracellular signal transduction
dopamine metabolic process
negative regulation of smooth muscle cell proliferation
regulation of blood vessel size
