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产品信息
PA5-95912
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human NR0B1 (NP_0004662)
偶联物
形式
Liquid
浓度
3.33 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807714
产品详细信息
Immunogen sequence: MAGENHQWQG SILYNMLMSA KQTRAAPEAP ETRLVDQCWG CSCGDEPGVG REGLLGGRNV ALLYRCCFCG KDHPRQGSIL YSMLTSAKQT YAAPKAPEAT LGPCWGCSCG SDPGVGRAGL PGGRPVALLY RCCFCGEDHP RQGSILYSLL TSSKQTHVAP AAPEARPGGA WWDRSYFAQR PGGKEALPGG RATALLYRCC FCGEDHPQQG STLYCVPTST NQAQAAPEER PRAPWWDTSS GALRPVALKS PQVVCEAASA; Positive Samples: HeLa, Jurkat, MCF7, HepG2, Raji, Mouse spleen; Cellular Location: Cytoplasm, Nucleus
靶标信息
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DAX 1; DSS-AHC critical region on the X chromosome protein 1; nuclear hormone receptor; Nuclear receptor DAX-1; Nuclear receptor subfamily 0 group B member 1; nuclear receptor subfamily 0, group B, member 1; R0B1
基因别名: AHC; AHCH; AHX; DAX-1; DAX1; DSS; GTD; HHG; NR0B1; NROB1; SRXY2
UniProt ID: (Human) P51843, (Mouse) Q61066
Entrez Gene ID: (Human) 190, (Mouse) 11614
DNA binding
steroid hormone receptor activity
transcription corepressor activity
RNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
DNA hairpin binding
steroid hormone receptor binding
protein homodimerization activity
sequence-specific DNA binding
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
steroid biosynthetic process
spermatogenesis
protein localization
gonad development
male gonad development
hypothalamus development
pituitary gland development
male sex determination
adrenal gland development
intracellular receptor signaling pathway
negative regulation of intracellular steroid hormone receptor signaling pathway
Leydig cell differentiation
response to immobilization stress
steroid hormone mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of cell differentiation
negative regulation of transcription, DNA-templated
Sertoli cell differentiation
