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NR0B2 Antibody (MA5-26786) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human lymphoma tissue. To expose target proteins, 1 mM EDTA in 10mM Tris, pH8.0 was used. Following antigen retrieval, tissues were probed with a NR0B2 monoclonal antibody (Product # MA5-26786) at a dilution of 1:150.
产品信息
MA5-26786
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
OTI7B5
抗原
Full length human recombinant protein of NR0B2 produced in E.coli
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2724863
靶标信息
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Nr0b2a; nuclear receptor SHP; Nuclear receptor subfamily 0 group B member 2; nuclear receptor subfamily 0, group B, member 2; Orphan nuclear receptor SHP; Small heterodimer partner
基因别名: NR0B2; SHP; SHP1
UniProt ID: (Human) Q15466
Entrez Gene ID: (Human) 8431
DNA binding
steroid hormone receptor activity
transcription corepressor activity
protein binding
transcription factor binding
protein domain specific binding
protein complex binding
protein homodimerization activity
peroxisome proliferator activated receptor binding
retinoid X receptor binding
thyroid hormone receptor binding
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
Notch signaling pathway
cholesterol metabolic process
response to glucose
positive regulation of gene expression
negative regulation of gene expression
organ regeneration
positive regulation of insulin secretion
steroid hormone mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
