Invitrogen

NR2C2 Monoclonal Antibody (OTI4B1)

NR2C2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NR2C2 Antibody (MA5-26855) in IHC (P)

Immunohistochemistry was performed on paraffin-embedded human lymphoma tissue. To expose target proteins, heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min. Following antigen retrieval, tissues were probed with a NR2C2 monoclonal antibody (Product # MA5-26855) at a dilution of 1:150.

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产品信息

MA5-26855

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:2,000

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免疫组化（石蜡） (IHC (P))

1:150

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

OTI4B1

抗原

Human recombinant protein fragment corresponding to amino acids 1-241 of NR2C2 produced in E.coli

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 1% BSA, 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2724870

靶标信息

Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. The proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Testicular orphan receptor 4 (TR4) promotes papillary thyroid cancer invasion via activating circ-FNLA/miR-149-5p/MMP9 signaling.

Molecular therapy. Nucleic acids

Ouyang X,Feng L,Yao L,Xiao Y,Hu X,Zhang G,Liu G,Wang Z

MA5-26855 was used in Western Blot to investigate the oncogenic role of testicular orphan receptor 4 in papillary thyroid cancer development.

Fri Jun 04 00:00:00 UTC 2021

Testicular orphan receptor 4 (TR4) promotes papillary thyroid cancer invasion via activating circ-FNLA/miR-149-5p/MMP9 signaling.

Molecular therapy. Nucleic acids

Ouyang X,Feng L,Yao L,Xiao Y,Hu X,Zhang G,Liu G,Wang Z

MA5-26855 was used in Western Blot to investigate the oncogenic role of testicular orphan receptor 4 in papillary thyroid cancer development.

Fri Jun 04 00:00:00 UTC 2021

miR-616-5p Promotes Invasion and Migration of Bladder Cancer via Downregulating NR2C2 Expression.

Frontiers in oncology

Ren W,Hu J,Li H,Chen J,Ding J,Zu X,Fan B

Published figure using NR2C2 monoclonal antibody (Product # MA5-26855) in Western Blot

Fri Apr 29 00:00:00 UTC 2022

生物信息学

蛋白别名: Nuclear hormone receptor TR4; Nuclear receptor subfamily 2 group C member 2; nuclear receptor subfamily 2, group C, member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; orphan receptor TR4; testicular nuclear receptor 4; Testicular receptor 4; TR2R1

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基因别名: NR2C2; TAK1; TR4

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UniProt ID: (Human) P49116

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Entrez Gene ID: (Human) 7182

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功能

transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription coactivator activity receptor activity protein binding zinc ion binding sequence-specific DNA binding protein heterodimerization activity C4 zinc finger nuclear receptor

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