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Product Details
PA5-28347
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 143 and 541 of Human NR5A2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2545823
Product Specific Information
Recommended positive controls: mouse liver, Aspc1.
Predicted reactivity: Mouse (88%), Rat (88%), Zebrafish (82%), Japanese Medaka (83%), Xenopus laevis (91%), Pig (96%), Chicken (96%), Sheep (95%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alpha-1-fetoprotein transcription factor; B1-binding factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; CYP7A promoter-binding factor; fetoprotein transcription factor; fetoprotein-alpha 1 (AFP) transcription factor; FTZ F1; FTZ F1beta; hB1F; hB1F 2; Hepatocytic transcription factor; hepatocytic transcription factor hB1F-3; live; liver nuclear receptor homolog-1 variant 2; Liver receptor homolog 1; LRH-1; Nuclear receptor subfamily 5 group A member 2; nuclear receptor subfamily 5, group A, member 2
Gene Aliases: AU020803; B1F; B1F2; CPF; D1Ertd308e; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1; NR5A2; UF2-H3B
UniProt ID: (Human) O00482, (Mouse) P45448
Entrez Gene ID: (Human) 2494, (Mouse) 26424
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
phospholipid binding
zinc ion binding
sequence-specific DNA binding
transcription regulatory region DNA binding
double-stranded DNA binding
lipid binding
metal ion binding
C4 zinc finger nuclear receptor
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
bile acid metabolic process
hormone-mediated signaling pathway
embryo development
tissue development
intracellular receptor signaling pathway
epithelial cell differentiation
regulation of cell proliferation
homeostatic process
cholesterol homeostasis
steroid hormone mediated signaling pathway
positive regulation of viral genome replication
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
pancreas morphogenesis
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
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