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NSD2 Antibody (MA5-24621) in ICC/IF
Immunofluorecent analysis of NSD2 in U-251 cells using NSD2 Monoclonal Antibody (CL1063) (Product # MA5-24621). Staining shows specific staining in the nucleoplasm in green. Microtubule- and nuclear probes are visualized in red and blue, respectively (where available).
产品信息
MA5-24621
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
CL1063
抗原
Recombinant protein corresponding to Human NSD2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2637236
产品详细信息
Immunogen sequence: SANGKTPSCE VNRECSVFLS KAQLSSSLQE GVMQKFNGHD ALPFIPADKL KDLTSRVFNG EPGAHDAKLR FESQEMKGIG TPPNTTPIKN GSPEIKLKIT KTYMNGKPLF ESSICGD
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.
Binds to an epitope located within the peptide sequence ALPFIPADKL as determined by overlapping synthetic peptides.
靶标信息
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Histone-lysine N-methyltransferase NSD2; IL5 promoter REII region-binding protein; MMSET; multiple myeloma SET domain containing protein type III; Multiple myeloma SET domain-containing protein; nuclear receptor binding SET domain protein 2; Nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; Protein trithorax-5; trithorax/ash1-related protein 5; Wolf-Hirschhorn syndrome candidate 1 protein
基因别名: KIAA1090; MMSET; NSD2; REIIBP; TRX5; WHS; WHSC1
UniProt ID: (Human) O96028
Entrez Gene ID: (Human) 7468
negative regulation of transcription from RNA polymerase II promoter
membranous septum morphogenesis
atrial septum primum morphogenesis
atrial septum secundum morphogenesis
double-strand break repair via nonhomologous end joining
transcription, DNA-templated
anatomical structure morphogenesis
histone H3-K36 methylation
chromatin modification
histone H4-K20 methylation
positive regulation of isotype switching to IgA isotypes
bone development
regulation of establishment of protein localization
regulation of double-strand break repair via nonhomologous end joining
