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NSG1 Antibody (PA5-101719) in ICC/IF
Immunocytochemistry analysis of NSG1 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with NSG1 polyclonal antibody (Product # PA5-101719) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-101719
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NSG1(Accession P42857), corresponding to amino acid residues A111-V161.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851152
产品详细信息
Antibody detects endogenous levels of total NSG1.
靶标信息
NEEP21 (neuron-enriched endosomal 21kDa protein), also known as brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family. It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues. NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons. It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties. In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (Neurotensin receptor 2).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: brain neuron cytoplasmic protein 1; Brain neuron cytoplasmic protein 1/2; brain specific mRNA b; carboxyterminally EE-tagged neuron-enriched endosomal 21 kDa protein; M234; Neuron-enriched endosomal protein of 21 kDa; Neuron-specific protein family member 1; Neuronal vesicle trafficking-associated protein 1; p21
基因别名: Bsmrb; D4S234; D4S234E; m234; NEEP21; NSG1; P21; PEP1
UniProt ID: (Human) P42857, (Mouse) Q62092, (Rat) P02683
Entrez Gene ID: (Human) 27065, (Mouse) 18196, (Rat) 25247
