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产品信息
PA5-58155
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2644820
产品详细信息
Immunogen sequence: PFVFIPEDDP LFPPIEKFYA LDPSFPRMNL LTRTTEGKKR QLYMVSKELR NVLLNNSEKM KVINTGIKVW CRNNSGEEFD CAFRLAQ
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
靶标信息
NSUN2 encodes a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu(CAA). Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu(CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Mutations of NSUN2 result in autosomal recessive 5 mental retardation (MRT5).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5-methycytoisine methyltransferase; hTrm4; Misu; mRNA cytosine C(5)-methyltransferase; Myc-induced SUN domain-containing protein; Myc-induced SUN-domain-containing protein; NOL1/NOP2/Sun domain family member 2; NOL1/NOP2/Sun domain family, member 2; NOP2/Sun domain family, member 2; NOP2/Sun RNA methyltransferase family, member 2; RNA cytosine C(5)-methyltransferase NSUN2; Substrate of AIM1/Aurora kinase B; tRNA (cytosine-5-)-methyltransferase NSUN2; tRNA cytosine C(5)-methyltransferase; tRNA methyltransferase 4 homolog
基因别名: MISU; MRT5; NSUN2; SAKI; TRM4
UniProt ID: (Human) Q08J23
Entrez Gene ID: (Human) 54888
