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Recommended positive controls: U87-MG, SK-N-SH, IMR-32, SK-N-AS, rat brain.
Predicted reactivity: Mouse (99%), Chicken (94%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD73; Neuropathy target esterase; patatin-like phospholipase domain containing 6; Patatin-like phospholipase domain-containing protein 6; Swiss cheese; Swiss-cheese
基因别名: AI661849; BNHS; iPLA2delta; LNMS; MSws; NTE; NTEMND; OMCS; PNPLA6; RGD1564611; SPG39; sws
UniProt ID: (Human) Q8IY17, (Mouse) Q3TRM4
Entrez Gene ID: (Human) 10908, (Mouse) 50767, (Rat) 360753