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Product Details
PA5-32953
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 20 amino acid peptide from internal region of human NTSR2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550414
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Monkey, Bovine, Dog, Pig (95%); Marmoset, Mouse, Rat (90%); Hamster (85%); Rabbit (80%).
For IHC(P), use proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Levocabastine-sensitive neurotensin receptor; Neurotensin receptor type 2; neurotensin receptor, type 2; NT-R-2; NT2 receptor
Gene Aliases: NTR2; NTSR2
UniProt ID: (Human) O95665
Entrez Gene ID: (Human) 23620
Performance Guarantee
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