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产品信息
MA5-42610
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
7Y9M2
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NUDT5 (Q9UKK9).
偶联物
形式
Liquid
浓度
1.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2911751
产品详细信息
Positive test controls include: HeLa, HepG2, A-431, Mouse thymus, Mouse liver, Rat kidney.
Immunogen sequence: MESQEPTESS QNGKQYIISE ELISEGKWVK LEKTTYMDPT GKTRTWESVK RTTRKEQTAD GVAVIPVLQR TLHYECIVLV KQFRPPMGGY CIEFPAGLID
靶标信息
Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 8-oxo-dGDP phosphatase; ADP-sugar pyrophosphatase; Nuclear ATP-synthesis protein NUDIX5; Nucleoside diphosphate-linked moiety X motif 5; nudix (nucleoside diphosphate linked moiety X)-type motif 5; Nudix motif 5; nudix-type motif 5; YSA1H
基因别名: HSPC115; NUDIX5; NUDT5; YSA1; YSA1H; YSAH1
UniProt ID: (Human) Q9UKK9, (Rat) Q6AY63, (Mouse) Q9JKX6
Entrez Gene ID: (Human) 11164, (Rat) 361274, (Mouse) 53893
magnesium ion binding
protein binding
nucleotidyltransferase activity
ADP-sugar diphosphatase activity
snoRNA binding
protein homodimerization activity
8-oxo-dGDP phosphatase activity
ADP-ribose diphosphatase activity
m7G(5')pppN diphosphatase activity
nucleoside-diphosphatase activity
RNA binding
hydrolase activity
metal ion binding
pyrophosphatase
