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NUMBL Antibody (A301-719A) in IP
Detection of human NUMBL1 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-NUMBL1 antibody (Product # A301-719A) used for IP at 3 µg/mg lysate. NUMBL1 was also immunoprecipitated by rabbit anti-NUMBL1 antibody A301-718A, which recognizes an upstream epitope. For blotting immunoprecipitated NUMBL1, A301-719A was used at 1 µg/mL. Detection: Chemiluminescence with an exposure time of 3 seconds.
产品信息
A301-719A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 545 and 595 of human numb (Drosophila) homolog-like.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
phosphate/tris citrate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: numb homolog (Drosophila)-like; numb homolog-like; Numb-like protein; Numb-R; Numb-related protein
基因别名: CAG3A; CTG3a; NBL; NUMB-R; NUMBL; NUMBLIKE; NUMBR; TNRC23
UniProt ID: (Human) Q9Y6R0
Entrez Gene ID: (Human) 9253
