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NaV1.5 (SCN5A) (1978-2016) Antibody (ASC-013-200UL) in IHC (P)
Expression of NaV1.5 in rat cardiac muscle - Immunohistochemical staining of NaV1.5 in ratmyocardiumparaffin-embedded section using Anti-NaV1.5 (SCN5A) (1978-2016) Antibody (#ASC-013), (1:100). Staining is specific for cardiomyocytes while smooth muscles cells in the artery walls are negative (red arrows). Hematoxilin is used as the counterstain.
产品信息
ASC-013-200UL
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GSTfusion protein with amino acid residues 1978-2016 of human NaV1.5, Intracellular, C-terminus
偶联物
形式
Lyophilized
浓度
0.95 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
Scn5a is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. Scn5a is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in Scn5a are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms of Scn5a. Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. Expression of Scn5a is also detected in lymphocytes, glia, and fibroblasts. Further, Scn5a mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Scn5a forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Functionally, Scn5a is responsible for the initial upstroke of the action potential and the channel inactivation is regulated by intracellular calcium levels. Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. Scn5a are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Diseases associated with SCN5A include Long Qt Syndrome-3 and Brugada Syndrome 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CDCD2VF1; CIN5; hH1; HH1CMD1E; LQT3SSS1CMPD2; RATRSKM2X; RH1; RSkM2; RSKM2X; Scn2x; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein type V subunit alpha; sodium channel, voltage gated, type V alpha subunit; sodium channel, voltage-gated, type 5, alpha subunit; sodium channel, voltage-gated, type V, alpha polypeptide; sodium channel, voltage-gated, type V, alpha subunit; voltage-gated sodium channel Nav1.5c; Voltage-gated sodium channel subunit alpha Nav1.5
基因别名: CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SCAL; SCN5A; SSS1; VF1
UniProt ID: (Human) Q14524, (Rat) P15389
Entrez Gene ID: (Human) 6331, (Rat) 25665
voltage-gated sodium channel activity
protein binding
calmodulin binding
fibroblast growth factor binding
enzyme binding
protein kinase binding
protein domain specific binding
ankyrin binding
ubiquitin protein ligase binding
ion channel binding
nitric-oxide synthase binding
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
voltage-gated sodium channel activity involved in AV node cell action potential
voltage-gated sodium channel activity involved in bundle of His cell action potential
voltage-gated sodium channel activity involved in Purkinje myocyte action potential
voltage-gated sodium channel activity involved in SA node cell action potential
scaffold protein binding
voltage-gated ion channel
regulation of heart rate
cardiac ventricle development
brainstem development
sodium ion transport
positive regulation of sodium ion transport
response to denervation involved in regulation of muscle adaptation
neuronal action potential
telencephalon development
cerebellum development
sodium ion transmembrane transport
odontogenesis of dentin-containing tooth
positive regulation of action potential
positive regulation of epithelial cell proliferation
membrane depolarization
cardiac muscle contraction
regulation of postsynaptic membrane potential
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of atrial cardiac muscle cell membrane depolarization
regulation of atrial cardiac muscle cell membrane repolarization
regulation of ventricular cardiac muscle cell membrane depolarization
cardiac conduction
cellular response to calcium ion
cardiac muscle cell action potential involved in contraction
regulation of cardiac muscle cell contraction
ventricular cardiac muscle cell action potential
membrane depolarization during action potential
membrane depolarization during cardiac muscle cell action potential
SA node cell action potential
AV node cell action potential
bundle of His cell action potential
membrane depolarization during AV node cell action potential
membrane depolarization during SA node cell action potential
membrane depolarization during Purkinje myocyte cell action potential
membrane depolarization during bundle of His cell action potential
AV node cell to bundle of His cell communication
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transport
positive regulation of heart rate
response to organic cyclic compound
regulation of ion transmembrane transport
bundle of His cell to Purkinje myocyte communication
SA node cell to atrial cardiac muscle cell communication
