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Immunogen sequence: SVNGSHKYKG NSKDVKPPDL WIHHERLELK PIDKSPDPNP IMTDTPIPRN SQDITPVDNS MDSNIHQRRN SYRGHESEDS MSTLAGR
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: HsT17534; Immunoglobulin superfamily DCC subclass member 2; NEO; Neogenin; neogenin homolog 1; NGNDKFZp547A066
基因别名: IGDCC2; NEO1; NGN; NTN1R2
UniProt ID: (Human) Q92859
Entrez Gene ID: (Human) 4756