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Neurexin 3 alpha (extracellular) Polyclonal Antibody

Neurexin 3 alpha (extracellular) Antibody in Immunohistochemistry (IHC)

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Neurexin 3 alpha (extracellular) Antibody (ANR-033-200UL) in IHC

Expression ofNeurexin 3 alpha in rat and mouse brain - Immunohistochemical staining of rat entorhinal cortex (A) and mouse striatum and lateral septum (B) using Anti-Neurexin 3 alpha (extracellular) Antibody (#ANR-033), (1:400). A. Nrxn3 alpha staining (green) appears in neuronal outlines in entorhinal cortex (arrow). B. Nrxn3 alpha staining appeared in axonal processes in striatum (horizontal arrow) and in... View More

Neurexin 3 alpha (extracellular) Antibody in Western Blot (WB)

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产品信息

ANR-033-200UL

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200

免疫组化 (IHC)

1:400

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)RYLRWDASTRSDLS, corresponding to amino acid residues 39-52 of rat Nrxn3 alpha, Extracellular, N-terminus

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.85 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

靶标信息

Neurexins comprise a family of neuronal cell surface proteins, which include neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3) and Caspr (neurexin IV). Neurexins I-III are expressed as a and b isoforms. The a isoforms are made of three cassettes, which contain two LNS (Laminin A, Neurexins, Sex hormone-binding)-domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal. The a isoforms bind to neurexophilins at the second LNS site and to the excitatory neurotoxin a-latrotoxin. The b isoforms have only one LNS-domain, bind to neuroligins, and play a role in the formation and remodeling of synapes. Caspr (for Contactin-Associated Protein 1, also designated Paranodin in mouse), contains an extracellular domain similar to the other three neurexins, and binds to the surface glycoprotein Contactin. Caspr and the closely related Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. Specifically, Caspr exists at the paranodal junctions, while Caspr2 colocalizes with Shaker-like K+ channels in the juxtaparanodal region. Caspr may play a role in the communication of glial cells and neurons during development.

仅用于科研。不用于诊断过程。未经明确授权不得转售。