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NeuroD1 Antibody (MA5-55297) in WB
Western blot analysis of lysates from mouse brain, using NeuroD1 Recombinant Monoclonal Antibody (Product # MA5-55297) at 1:1,000 dilution followed by an HRP-conjugated Goat anti-Rabbit IgG (H+L) secondary antibody at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
MA5-55297
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5V4L8
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NeuroD1.
偶联物
形式
Liquid
浓度
1.33 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
产品详细信息
Immunogen Sequence: MTKSYSESGL MGEPQPQGPP SWTDECLSSQ DEEHEADKKE DDLETMNAEE DSLRNGGEEE DEDEDLEEEE EEEEEDDDQK PKRRGPKKKK MTKARLERFK
靶标信息
NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Beta-cell E-box transcriptional activator 2; Beta2; BHF1; neuro d1; NeuroD1; Neurogenic differentiation factor 1
基因别名: BETA2; BHF-1; bHLHa3; Neurod; Neurod1
UniProt ID: (Mouse) Q60867
Entrez Gene ID: (Mouse) 18012
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription coactivator activity
DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription factor binding
sequence-specific DNA binding
protein heterodimerization activity
protein dimerization activity
E-box binding
basic helix-loop-helix transcription factor
pancreatic A cell fate commitment
pancreatic PP cell fate commitment
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
nucleocytoplasmic transport
nitric oxide mediated signal transduction
multicellular organism development
nervous system development
response to glucose
anterior/posterior pattern specification
dentate gyrus development
cerebellum development
signal transduction involved in regulation of gene expression
insulin secretion
cell differentiation
hindbrain development
endocrine pancreas development
amacrine cell differentiation
enteroendocrine cell differentiation
glucose homeostasis
camera-type eye development
positive regulation of apoptotic process
cell fate commitment
positive regulation of cell differentiation
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JAK-STAT cascade
embryonic organ morphogenesis
inner ear development
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of intestinal epithelial structure maintenance
regulation of cell cycle arrest
cellular response to glucose stimulus
negative regulation of type B pancreatic cell apoptotic process
positive regulation of transcription regulatory region DNA binding
