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NeoBiotechnologies
Neurofilament (H+L) (Neuronal Marker) Monoclonal Antibody (RT-97, NR-4)
产品信息
MSM2-1201-P1ABX
应用
建议稀释比
已发表文章
产品规格
种属反应
Chicken,
Human,
Mouse,
Pig,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
RT-97, NR-4
抗原
Triton-X 100 insoluble proteins of rat brain (RT-97). Neurofilaments from porcine spinal cord (NR-4)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 200 kDa neurofilament protein; 68 kDa neurofilament protein; light molecular weight neurofilament protein; neurofilament 200kDa; Neurofilament heavy polypeptide; Neurofilament light polypeptide; neurofilament protein L; neurofilament protein, light chain; neurofilament subunit NF-L; Neurofilament triplet H protein; Neurofilament triplet L protein; neurofilament, heavy polypeptide 200kDa; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; NF-H; NF-L; protein phosphatase 1, regulatory subunit 110
基因别名: AI847934; CMT1F; CMT2CC; CMT2E; KIAA0845; mKIAA0845; NEFH; NEFL; NF-H; NF-L; NF200; NF68; NFH; NFL; PPP1R110
UniProt ID: (Human) P12036, (Human) P07196, (Mouse) P19246, (Mouse) P08551, (Rat) P19527
Entrez Gene ID: (Human) 4744, (Pig) 100156492, (Chicken) 417020, (Human) 4747, (Chicken) 419528, (Pig) 100521224, (Rat) 24587, (Mouse) 380684, (Mouse) 18039, (Rat) 83613
structural molecule activity
structural constituent of cytoskeleton
microtubule binding
toxic substance binding
kinesin binding
protein kinase binding
protein binding, bridging
dynein binding
protein heterodimerization activity
Ras guanyl-nucleotide exchange factor activity
protein binding
protein C-terminus binding
protein domain specific binding
identical protein binding
phospholipase binding
nutrient reservoir activity
MAPK cascade
microtubule cytoskeleton organization
anterograde axonal transport
retrograde axonal transport
response to toxic substance
peripheral nervous system axon regeneration
axonal transport of mitochondrion
spinal cord development
hippocampus development
cerebral cortex development
regulation of axon diameter
neurofilament bundle assembly
locomotion
response to peptide hormone
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
intermediate filament polymerization or depolymerization
intermediate filament organization
neuron projection morphogenesis
positive regulation of axonogenesis
neuromuscular process controlling balance
protein polymerization
response to corticosterone
response to sodium arsenite
response to acrylamide
axon development
ovarian follicle atresia
axonogenesis
cell projection assembly
axon regeneration
cellular response to oxidative stress
response to cocaine
peripheral nervous system neuron axonogenesis
cellular response to estradiol stimulus
regulation of organelle transport along microtubule
intermediate filament bundle assembly
neurofilament cytoskeleton organization
brain development
embryo development
neuron projection development
intermediate filament cytoskeleton organization
response to organic substance
response to organonitrogen compound
