Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-40478
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the C-terminal of human NEUROG1 (aa 180-229).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2606240
产品详细信息
Peptide sequence: ASDAESWGSG AAAASPLSDP SSPAASEDFT YRPGDPVFSF PSLPKDLLHT
Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 79%; Rat: 93%
靶标信息
Neurogenin 1 is a basic helix-loop-helix (bHLH) proteins are transcription factors involved in determining cell type during development. NeuroG1 is a bHLH protein with dual cell-fate specification roles. It functions during neurogenesis, and it has also been shown to inhibit the differentiation of neural stem cells into astrocytes. NeuroG1 promotes neurogenesis by functioning as a transcriptional activator, yet it inhibits astrocyte differentiation by compartmentalizing the CREB-binding protein transcription complex away from astrocyte differentiation genes and by inhibiting STAT transcription factors essential for gliogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: bHLHa6; Class A basic helix-loop-helix protein 6; Helix-loop-helix protein mATH-4C; mATH4C; NeuroD3; Neurogenic basic-helix-loop-helix protein; neurogenic differentiation 3; Neurogenic differentiation factor 3; Neurogenin-1; NGN-1
基因别名: AKA; Ath4c; BHLHA6; Math4C; NEUROD3; NEUROG1; NGN; NGN1
UniProt ID: (Human) Q92886, (Mouse) P70660
Entrez Gene ID: (Human) 4762, (Mouse) 18014
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
neuron differentiation
positive regulation of exit from mitosis
inner ear morphogenesis
cell fate commitment
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of transcription, DNA-templated
multicellular organism development
neurogenesis
cell differentiation
regulation of neuron differentiation
