Invitrogen

Neurogenin 1 Monoclonal Antibody (OTI3F9)

Neurogenin 1 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 12

Neurogenin 1 Antibody (MA5-24900) in ICC/IF

Immunofluorescent analysis of NEUROG1 in COS7 cells. Cells were transfected with a plasmid overexpressing NEUROG1 and probed with a NEUROG1 monoclonal antibody (Product # MA5-24900).

Neurogenin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Neurogenin 1 Antibody in Western Blot (WB)

Product Image Gallery

产品信息

MA5-24900

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50

免疫细胞化学 (ICC/IF)

1:100

免疫沉淀 (IP)

2-4 µg/mL

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

OTI3F9

抗原

Full length human recombinant protein of NEUROG1 produced in HEK293T cell

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 1% BSA, 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2724828

靶标信息

Neurogenin 1 is a basic helix-loop-helix (bHLH) proteins are transcription factors involved in determining cell type during development. NeuroG1 is a bHLH protein with dual cell-fate specification roles. It functions during neurogenesis, and it has also been shown to inhibit the differentiation of neural stem cells into astrocytes. NeuroG1 promotes neurogenesis by functioning as a transcriptional activator, yet it inhibits astrocyte differentiation by compartmentalizing the CREB-binding protein transcription complex away from astrocyte differentiation genes and by inhibiting STAT transcription factors essential for gliogenesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Effects of environmental chemicals on the proliferation and differentiation of neural stem cells.

Environmental toxicology

Huang M,Li Y,Wu K,Hao S,Cai Q,Zhou ZJ,Yang HF

MA5-24900 was used in Western Blotting to demonstrate that environmental chemicals can impair the proliferation and differentiation of NSCs, which may cause abnormal development of the nervous system.

Sun Dec 01 00:00:00 UTC 2019

生物信息学

蛋白别名: bHLHa6; Class A basic helix-loop-helix protein 6; NeuroD3; Neurogenic basic-helix-loop-helix protein; neurogenic differentiation 3; Neurogenic differentiation factor 3; Neurogenin-1; NGN-1

查看更多收起

基因别名: AKA; BHLHA6; Math4C; NEUROD3; NEUROG1; NGN; NGN1

查看更多收起

UniProt ID: (Human) Q92886

查看更多收起

Entrez Gene ID: (Human) 4762

查看更多收起

功能

transcription factor activity, transcription factor binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding protein dimerization activity E-box binding basic helix-loop-helix transcription factor

参与通路